Pipe re-sizing of water distribution networks (WDNs) aims at improving the service performance to the required level, while minimizing the cost of replacing pipes in the network.The main challenge comes from the identification of the most effective pipes to re-size from a large number of interacting components.Performing a global search over all pi
Abstract Due to their important phylogenetic position among extant vertebrates, sharks are an invaluable group in evolutionary developmental biology studies.A thorough understanding of shark anatomy is essential to facilitate these studies and documentation of this iconic taxon.With the increasing availability of cross-sectional imaging techniques,
Introduction.Bronchogenic cysts are rare congenital anomalies of the embryonic foregut.They are caused by abnormal budding of diverticulum of the embryonic foregut between the 26th and 40th day of gestation.Bronchogenic cysts can appear in the mediastinum and pulmonary parenchyma, or at ectopic sites (neck, subcutaneous tissue or abdomen).So far, 7
Abstract Lon is a conserved AAA+ (ATPases associated with diverse cellular activities) proteolytic machine that plays a key regulatory role in cells under proteotoxic stress.Lon-mediated proteolysis can be stimulated by either the unfolded or specific protein substrates accumulated under stress conditions.However, the molecular basis for this Styli